Water Solubility Enhancement of Atorvastatin by Solid Dispersion Method
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چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drugs by Solid Dispersion
Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...
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Carvedilol is an effective nonselective alpha-1 and beta blocker discovered by Fritz Wiedemann [1] . It is an antihypertensive drug indicated for the treatment of mild to severe congestive heart failure (CHF), angina pectoris, cardiac arrhythmias and myocardial infarction [2] . Water solubility of Carvedilol is a fundamental property that affects the drug absorption after oral administration. M...
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Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature in...
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Paracetamol (PCM) is a non-steroidal anti-inflammatory drug (NSAID), sparingly soluble and bitter in taste. It is widely used as an analgesic and antipyretic. Solid dispersion of drug with different polymers was attempted to improve solubility of paracetamol.The aim of this study was to prepare, characterize and compare solid dispersions of poorly water soluble non-steroidal anti-inflammatory d...
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ژورنال
عنوان ژورنال: Stamford Journal of Pharmaceutical Sciences
سال: 1970
ISSN: 1999-7108
DOI: 10.3329/sjps.v3i2.8036